DesigneRx was founded in Vacaville, CA in 2002. Construction of the first GMP manufacturing facility began in 2003. The first clinical lot of pegylated arginine deiminase was produced in 2005. In 2013 construction began on a second larger GMP manufacturing facility, new process development laboratories, a new GMP warehouse, and a new Quality Control laboratory. DesigneRx has manufactured clinical materials for trials in the United States, Europe, and Asia.